Sleep
Circuit mechanism underlying fragmented sleep and memory deficits in 16p11.2 deletion mouse model of autism. Choi A, Smith J, Wang Y, Shin H, Kim B, Wiest A, Jin X, An I, Hong J, Antila H, Thomas S, Bhattarai JP, Beier KT, Ma M, Weber F and Chung S. BioRxiv 573156. [Preprint]. Dec 27, 2023.
Infralimbic activity during REM sleep facilitates fear extinction memory. Hong J, Choi K, Fuccillo MV, Chung S, and Weber F. BioRxiv 576390. [Preprint]. Jan 22, 2024. Current Biology. 2024 In press
Homeostatic regulation of REM sleep by the preoptic area of the hypothalamus Maurer J, Lin A, Jin X, Hong J, Sathi N, Cardis R, Osorio-Forero A, Lüthi A, Weber F and Chung S. eLife. 2023 In Press
Regulation of stress-induced sleep fragmentation by preoptic glutamatergic neurons Smith J, Honig-Frand A, Antila H, Kim H, Beier K, Weber F, Chung S. Current Biology. 2024 In press
Prefrontal cortical regulation of REM sleep. Hong J, Lozano DE, Beier KT, Chung S, Weber F. Nature Neuroscience. 2023; 26(10):1820-1832.
Sleep disturbances in autism spectrum disorder: animal models, neural mechanisms, and therapeutics. Maurer J, Choi A, An I, Sathi N, Chung S. Neurobiology of Sleep and Circadian Rhythms. 2023; 14:100095
Exploring NREM sleep substages in rats to develop biomarkers for depression. Wiest A, Chung S. Sleep. 2023; 46(7):zsad117
A noradrenergic-hypothalamic neural substrate for stress-induced sleep disturbances. Antila H, Kwak I, Choi A, Pisciotti A, Covarrubias I, Baik J, Eisch A, Beier K, Thomas S, Weber F, Chung S. PNAS. 2022; 119(45): e2123528119
A medullary hub for controlling REM sleep and pontine waves. Schott, A., Baik, J., Chung, S. and Weber, F., 2022. Nature Communication. 2023; 14(1):3922
Regulation of REM sleep by inhibitory neurons in the dorsomedial medulla. Stucynski JA, Schott AL, Baik J, Chung S, Weber F. Current Biology. 2021; 32: 1-14
A probabilistic model for the ultradian timing of REM sleep in mice. Park SH, Baik J, Hong J, Antila H, Kurland B, Chung S, Weber F. PLOS Computational Biology. 2021; 17(8):e1009316.
Role of the preoptic area in sleep and thermoregulation. Rothhaas R, Chung S. Frontiers in Neuroscience 2021
An excitatory circuit in the perioculomotor midbrain for non-REM sleep control. Zhang Z, Zhong P, Hu F, Barger Z, Ren Y, Ding X, Li S, Weber F, Chung S, Palmiter RD, Dan Y. Cell 2019; 177(5):1293-1307
Identification of preoptic sleep neurons using retrograde labeling and gene profiling. Chung S, Weber F, Zhong P, Tan CL, Nguyen TN, Beier KT, Hörmann N, Chang WC, Zhang Z, Do JP, Yao S, Krashes MJ, Tasic B, Cetin A, Zeng H, Knight ZA, Luo L, Dan Y. Nature. 2017 May 25;545(7655):477-481.
Control of REM sleep by ventral medulla GABAergic neurons. Weber F, Chung S, Beier KT, Xu M, Luo L, Dan Y. Nature. 2015 Oct 15;526(7573):435-8.
Basal forebrain circuit for sleep-wake control. Xu M*, Chung S*, Zhang S, Zhong P, Ma C, Chang WC, Weissbourd B, Sakai N, Luo L, Nishino S, Dan Y. Nature neuroscience. 2015 Nov 1;18(11):1641-7. *co-first author
Cell type-specific long-range connections of basal forebrain circuit. Do JP, Xu M, Lee SH, Chang WC, Zhang S, Chung S, Yung TJ, Fan JL, Miyamichi K, Luo L, Dan Y. eLife. 2016 Sep 19;5:e13214.
Neuropeptides and GPCRs
The melanin-concentrating hormone system modulates cocaine reward. Chung S, Hopf FW, Nagasaki H, Li CY, Belluzzi JD, Bonci A, Civelli O. Proceedings of the National Academy of Sciences. 2009 Apr 21;106(16):6772-7.
The pharmacological properties of a novel MCH 1 receptor antagonist isolated from combinatorial libraries. Nagasaki H*, Chung S*, Dooley CT, Wang Z, Li C, Saito Y, Clark SD, Houghten RA, Civelli O. European journal of pharmacology. 2009 Jan 14;602(2):194-202. *co-first author
The melanin-concentrating hormone (MCH) system modulates behaviors associated with psychiatric disorders. Chung S, Verheij MM, Hesseling P, Van Vugt RW, Buell M, Belluzzi JD, Geyer MA, Martens GJ, Civelli O. PloS one. 2011 Jul 19;6(7):e19286.
Disruption of the melanin-concentrating hormone receptor 1 (MCH1R) affects thyroid function. Chung S, Liao XH, Di Cosmo C, Van Sande J, Wang Z, Refetoff S, Civelli O. Endocrinology. 2012 Sep 28;153(12):6145-54.
Acute homeostatic responses to increased fat consumption in MCH1R knockout mice. Chung S, Wong T, Nagasaki H, Civelli O. Journal of molecular neuroscience. 2010 Nov 1;42(3):459-63.
Functional interaction of regulator of G protein signaling‐2 with melanin‐concentrating hormone receptor 1. Miyamoto‐Matsubara M, Chung S, Saito Y. Annals of the New York Academy of Sciences. 2010 Jul 1;1200(1):112-9.
Endogenous orphanin FQ/nociceptin is involved in the development of morphine tolerance. Chung S, Pohl S, Zeng J, Civelli O, Reinscheid RK. Journal of Pharmacology and Experimental Therapeutics. 2006 Jul 1;318(1):262-7.
Pharmacological characterization of human and murine neuropeptide s receptor variants. Reinscheid RK, Xu YL, Okamura N, Zeng J, Chung S, Pai R, Wang Z, Civelli O. Journal of Pharmacology and Experimental Therapeutics. 2005 Dec 1;315(3):1338-45.
Reviews
Recent updates on the melanin-concentrating hormone (MCH) and its receptor system: lessons from MCH1R antagonists. Chung S, Parks GS, Lee C, Civelli O. Journal of Molecular Neuroscience. 2011 Jan 1;43(1):115-21.
MCH receptors/gene structure-in vivo expression. Chung S, Saito Y, Civelli O. Peptides. 2009 Nov 30;30(11):1985-9.
Orphan GPCR research. Chung S, Funakoshi T, Civelli O. British journal of pharmacology. 2008 Mar 1;153(S1):S339-46.
Orphan neuropeptides: Novel neuropeptides modulating sleep or feeding. Chung S, Civelli O. Neuropeptides. 2006 Aug 31;40(4):233-43.
Earlier work
Cell-type specific regulation of serotonergic identity by the C. elegans LIM-homeodomain factor LIM-4. Zheng X, Chung S, Tanabe T, Sze JY. Developmental biology. 2005 Oct 15;286(2):618-28.